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Packaged and sealed 99.9% purity, unmixed, premium Phenacetin powder

Phenacetin powder
Other Name: Phenacetinum
Chemical Name: 1-Acetyl-p-Phenetidin；4-acetophenetidine
CAS: 62-44-2
MF: C10H13NO2
MW: 179.22
EINECS: 200-533-0
Assay: 99.9%
Appearence:White powder or white crystalline powder,No smell, taste slightly bitter.

Solubility:This product is difficult to dissolve in water, slightly soluble in ether, slightly soluble in boiling water, soluble in ethanol and chloroform. Dissolve in concentrated sulfuric acid, the color is not obvious, to the solution in the nitric acid is orange yellow.
Drug category: Antipyretic and analgesic drugs raw materials
Purpose: Antipyretic analgesics for the treatment of fever, headache, neuralgia, etc.

Phenacetin’s analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.

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It is metabolized in the body to paracetamol (acetaminophen), which is also a clinically relevant analgesic.
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an A.P.C., or “aspirin-phenacetin-caffeine” compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent’s APC in Australia.

As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche’s Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin’s carcinogenicity.

Phenacetin may be synthesized as an example of the Williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are heated in 2-butanone to give the crude product, which is recrystallized from water.

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